Abs9042 #LCSM #CHRYSALIS2: Amivantamab+lazertinib in post-osimertinib, chemo-naïve EGFR-mutated advanced NSCLC. 🔬 This approach revealed heterogeneity in real-world survival outcomesĦ. 📊 In in-silico trials, survival benefits varied across risk groups and were generally lower compared to RCTs, especially among high-risk patients. ➡️Best-performing gradient boosted model outperformed Lung Cancer Prognostic Index (AUC 0.784 vs 0.688). 🔍 New study leverages ML to simulate two pivotal trials in 1L aNSCLC with real-world data from 61,339 patients. 🔬 Combined Deep-IO+PD-L1 score improved AUROC to 0.82, 32% increase in specificity compared to PD-L1 alone. ➡️ Outperformed both PD-L1 expression and TMB in predictive power (AUROC=0.75). 🖥️ Training with 85218 tiles from 446 patients, the model achieved an accuracy of 0.72 in distinguishing responders from non-responders. 🧪 Novel AI tool, Deep-IO, shows promise in predicting response to ICIs in NSCLC using H&E images. ➡️ Underscores the potential of tepotinib in clinical practice.
DEEEP IO SPANISH TRIAL
🎯 Long-term outcomes of #VISION trial highlight robust and durable clinical activity of tepotinib in METex14 skipping NSCLC, particularly in 1L tissue+ patients. 🏁 Findings underscore the need for wider accessibility of NGS testing and education. ➡️ OS benefit associated with earlier targeted therapy initiation 💊. ➡️ Median OS longest in patients with upfront NGS vs. ➡️ Percentage of patients with upfront NGS increased from 29% in 2019 to 66% in 2022 📈. 🔬 Largest study yet showing upfront NGS testing leads to better OS compared to upfront non-NGS, later NGS, or no-NGS in aNSCLC 🧬. 🏁 Results inform future use of early ctDNA response assessment ➡️ Lack of treatment-induced decrease in ctDNA may predict inferior OS from cemi as early as 3 weeks into therapy 📌.
29 months (MR) and 8 months (no decrease) 🎯. ➡️ cemi patients with complete ctDNA clearance showed longest survival, median OS not reached vs. ➡️ ctDNA at W9 associated with clinical response to cemi, but not chemo 📉. 🔬 EMPOWER-Lung 1: Correlating ctDNA levels with outcomes in 1L aNSCLC treated with cemi or chemo 🧬. Category and Tags IO Games io multiplayer arena html5 grow Discuss Deeeep.👇🏼 some #LCSM #lungcancer studies of interest at American Society of Clinical Oncology (ASCO) #asco23 Animals with special abilities will use these abilities instead of speeding up when the boost bar is full. When you're in the sea, clicking will give you a speed boost as long as your boost bar is full. If you click, animals with the ability to walk across islands will jump to them. Your animal will wander to anywhere you point your cursor. One of the most special elements of the game is that it is based on the preferred open-source video game "Doom" - all of your steps are videotaped in real-time and also conserved for future games. Deeeep.io is an online multiplayer game where you can either play as a sea creature or a submarine, fighting against other players for region as well as food while trying to prevent being attacked by sharks. The Deeeep.io video game is the largest multiplayer online game of its time. One of the most unique aspects of the video game is that it is based on the prominent open-source game "Doom" - all of your relocations are recorded in real-time and saved for future video games. If you play the game well sufficient, you can even unlock different abilities like jetpacks, much more effective attacks, invisibility, and also a lot more!ĭeeeep.io is an online multiplayer video game where you can either play as a sea creature or a submarine, fighting against various other gamers for area and also food while trying to stay clear of being assaulted by sharks. You can swim up, try to consume them, or simply sink down as well as wait for your inescapable death. The idea of the Deeeep.io video game is simple: You begin as a fish in the deep sea, and also you try to survive against various other players that are additionally fish.
DEEEP IO SPANISH FREE
It’& rsquo s a free online multiplayer online video game that’has a retro 8-bit design that & rsquo s comparable to classic video games you may have played in the 1980s and 1990s. The Deeeep.io game is the best way to obtain your adrenaline pumping.
Much, more than 12 million players have actually fallen in love with this amazing sea world. In this free-to-play game, players can check out and battle across hundreds of islands trying to find prizes and also new experiences. The Deeeep.io game is the largest multiplayer online video game of its time. It is a superb game for involving in team activities with close friends or household members. It is one of the most prominent games in the world and has over 6 million players each day. About is a video game that is totally free, interactive, and readily available to play on any type of tool.
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